efficacy of memantine in acute non-arteritic ischemic optic neuropathy
نویسندگان
چکیده
purpose : evaluation of efficacy of memantine (n-methyl-d-aspartate receptor antagonist) on visual function of patients with acute non-arteritic ischemic optic neuropathy (naion). methods : the study was conducted as interventional case series from november 2005 through november 2006 in farabi eye hospital . twenty-two patients with acute naion of less than 8 weeks duration entered the study. memantine was prescribed with a dose of 5 mg per day for the first week and 10 mg per day for the following two weeks. baseline best corrected visual acuity (bcva) visual evoked potential (vep) and visual field was done for all patients. bcva recording repeated 3 weeks, 3 and 6 months later. vep and perimetry repeated 3 months after treatment. results : after 3 weeks, 3 and 6 months, bcva improved -0.32±0.40 logmar, -0.51±0.49 and -0.51±0.49, respectively (p=0.005, p=0.001 and p=0.001, respectively). vep recordings after 3 months, demonstrated -8.61±14.51 db mean decrease in implicit time (p=0.019). amplitude of voltage did not show significant difference with baseline (p=0.10). perimetry results after 3 months showed that mean deviation (md) improved 2.77± 3.94 db (p=0.016). conclusion : memantine resulted in significant improvement of bcva 3 weeks, 3 and 6 months after treatment of acute naion. memantine also resulted in significant decrease of implicit time and significant improvement of mean deviation in vep and perimetry after 3 months. iranian journal of ophthalmology 200820(3):39-44
منابع مشابه
vitreopapillary traction in non-arteritic anterior ischemic optic neuropathy
purpose: to describe the association between optic disc traction and non-arteritic anterior ischemic optic neuropathy (naion). methods: eighty three eyes of 83 patients with naion were evaluated by optical coherence tomography (oct) for detecting vitreous adhesion to the optic nerve head with separation from adjacent retina (partial posterior vitreous detachment). those who were negative for su...
متن کاملtransvitreal optic neurotomy for non-arteritic anterior ischemic optic neuropathy
purpose: to evaluate the role of transvitreal optic neurotomy (ton) in the management of non-arteritic anterior ischemic optic neurotomy (naion). methods: sixteen eyes of 16 patients with recent onset naion (less than six weeks duration) were included in this single-masked randomized controlled trial. the patients were randomized to ton (8 eyes) versus observation alone (8 eyes). pre- and posto...
متن کاملObstructive sleep apnea syndrome and non-arteritic anterior ischemic optic neuropathy: a case control study
Background: Sleep apnea is temporary cessation or absence of breathing during sleep. Significant increase in blood pressure is clinically seen in apneic episodes. The aim of this study was to examine sleep apnea syndrome as a risk factor for non- arthritic anterior ischemic optic neuropathy (NAION) in a case control study. Methods: Nineteen NAION patients (9 men and 10 women) and 31 age and ...
متن کاملNon-Arteritic Anterior Ischemic Optic Neuropathy (NAION)—A Brief Review
Ischemic optic neuropathies could be a result of inflammatory and non inflammatory small vessel disease and have been classified as arteritic and non-arteritic anterior ischemic optic neuropathy respectively. This review has been intended to elucidate the epidemiology, etiology, pathogenesis, clinical picture and management of NAION and the literature search was completed using the published da...
متن کاملNon-arteritic anterior ischemic optic neuropathy secondary to acute primary-angle closure
PURPOSE To describe a case of non-arteritic ischemic optic neuropathy (NAION) secondary to acute primary-angle closure (APAC). METHODS Case report. RESULTS A 50-year-old woman with painful visual loss in the right eye was found to be in APAC with a right afferent pupillary defect. Laser peripheral iridotomy relieved pain but did not improve vision. Diffuse optic disc edema in the right eye ...
متن کاملAcute Monocular Blindness after Carotid Endarterectomy due to Non-arteritic Anterior Ischemic Optic Neuropathy.
23 Stone DH, Goodney PP, Schanzer A, Nolan BW, Adams JE, Powell RJ, et al. Clopidogrel is not associated with major bleeding complications during peripheral artery surgery. J Vasc Surg 2011;54:779e84. 24 Wait SD, Abla AA, Killory BD, Starke RM, Spetzler RF, Nakaji P. Safety of carotid endarterectomy while on Clopidogrel (Plavix). J Neurosurg 2010;113:908e12. 25 Doig D, Turner EL, Dobson J, Feat...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of current ophthalmologyجلد ۲۰، شماره ۳، صفحات ۳۹-۴۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023